If you have read any of my earlier articles on nootropics, it’s no secret that I’m a big proponent of aniracetam. When I first started looking into smart drugs, I quickly discovered that piracetam was a substance that I couldn’t purchase in my country. From there, I went on to look at the other members of the racetam family, to find a viable substitute similar to piracetam that was available for purchase in Australia.

I was greatly disappointed that I couldn’t get hold of piracetam, I still am, as piracetam has a lot of research and anecdotal reports that speak of the legitimacy of this smart drug on overall cognition. From there I researched aniracetam, made my first purchase about two years ago, and haven’t looked back since. Aniracetam is part of my daily supplemental routine.

The question is – which one is better? Or, is one being better than the other? Maybe the question is more along the lines of – which one should a try first?

In this aniracetam vs piracetam review, I’ll endeavour to provide the information that will lead you to be able to make an informed decision for yourself.

Aniracetam vs Piracetam Review: Mechanisms of Action

The mechanisms of action for both compounds are a mixture of observed research and speculation. Below is a list of proposed and observed methods of action for both aniracetam and piracetam.


  • Stimulates the AMPA receptor
  • Influences the cholinergic and acetylcholine systems
  • Activates the D2 and D3 dopamine receptors
  • Stimulates the Nicotinic Ach receptor
  • Interacts with the 5-HTP serotonin receptor


  • Stimulates the AMPA receptor
  • Influences the cholinergic and acetylcholine systems
  • Influences the NMDA receptor
  • Stimulates the Nicotinic Ach receptor

Both the AMPA and NMDA receptors are crucial for memory and learning; indicating the possibility of cognitive enhancement whilst using the cholinergic and acetylcholine systems as “fuel for receptor activation. The proposed activation of the dopamine and serotonin receptors indicates the potential of aniracetam having a greater effect on mood than piracetam.

This to me is the main variable as to deciding which nootropic is the best one for you to use. Piracetam also seems to have a positive effect on mood, but not quite as great as what aniracetam does.

To view a graph on the benefits of aniracetam, piracetam, and other nootropics, along with linked studies click HERE.

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Potential Side Effects

Side effects of any nootropic from the racetam family are fairly rare and easy to manage. However, it is important to understand that there are potential side effects.

Taking a choline precursor, and sticking to the recommended doses will greatly minimize any possible side effects. The majority of us are choline deficient (about 90% of the population), it’s important to have a choline precursor on hand when taking any nootropic supplement.

Potential Side Effects of Aniracetam

  • Nausea
  • Headaches
  • Insomnia
  • Gastrointestinal issues

Potential Side Effects of Piracetam

  • Nausea
  • Headaches
  • Fatigue
  • Insomnia
  • Depression
  • Gastrointestinal issues

Positive Benefits of Aniracetam and Piracetam

Here’s the exciting part.

Aniracetam Benefits

  • Reductions in anxiety and depression
  • Improved learning
  • Increased memory
  • Increased sensory perception
  • Increased cognitive processing
  • Faster reflexes

Piracetam Benefits

  • Reduced brain trauma
  • Improved memory
  • Improved learning
  • Enhanced focus
  • Increased sensory perception
  • Reductions in anxiety and depression

Which One Should I Choose?

What are you looking for in a nootropic? As someone who had chronic PTSD related anxiety and stress, with two years of positive experience with aniracetam; I’d recommend aniracetam for anyone who wants to reduce anxiety and stress whilst increasing their cognition.

For someone who is not as concerned about their overall mood, but is more interested in increasing their cognition; I’d recommend piracetam.

However, nootropics have different effects on us due to the differences in our biochemical makeup. Some people prefer aniracetam over piracetam, and other prefer piracetam over aniracetam, and some stack the two together.

The key is to match up the benefits of the nootropic, along with the results that you are looking for. From there you can change, add on, take away, and work your way towards finding the nootropics that work best for you.

Aniracetam can be purchased HERE.

Piracetam can be purchased HERE.

Choline will enhance the effects of the nootropic and reduce the potential for headaches and other symptoms. There are different forms of choline, to read up more on what choline source to choose click HERE.


Important Recommendations

Always stick to the manufacturers recommended dosages. Once you have experiences with a particular nootropic, and how it affects you, then you can look into playing around with the dosages.

Don’t take a nootropic if you are planning on going to sleep a couple of hours later. Your brain will be more active, possibly resulting in insomnia.

Take note of how you feel when taking the supplements. Keep a physical or mental journal, that way you can track and quantify how the supplement affects you. Some first-time nootropic users don’t notice a change until after they stop taking the nootropic. Give the nootropics time to work their magic.


Related Posts

The Oxiracetam Aniracetam Stack: Calm and Focused

The Noopept Aniracetam Stack: Calm and Clear

Aniracetam for Anxiety, Stress, Depression and Cognition

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