Both of these smart drugs have great applications for performance hackers who are looking to increase their cognition and productivity. In this article, I’ll highlight the differences between the two nootropics, their methods of action and how they can help overall cognition.

Aniracetam and oxiracetam are great “beginner” nootropics when stacked with a choline precursor, yet both have distinct differences. When looking at aniracetam vs oxiracetam, it’s important to understand these differences, so we can make a more informed decision on what nootropic may be the one that we want to try, or add to a stack.



Aniracetam vs Oxiracetam Review: What’s the Difference?

Methods of Action

It’s been hard for researchers to establish the exact methods of action with aniracetam and oxiracetam, as our body and brain operates as a system. Below is a list of believed, and in some cases proven methods of action.


  • Stimulates the AMPA receptor
  • Influences the cholinergic and acetylcholine systems
  • Activates the D2 and D3 dopamine receptors
  • Stimulates the Nicotinic Ach receptor
  • Interacts with the 5-HTP serotonin receptor


  • Influences the choline and acetylcholine systems
  • Stimulates the AMPA and NMDA receptors


Aniracetam and Oxiracetam Benefits

The above lists allude to the benefits of both these nootropic supplements. We can clearly see the differences that they have in their reported methods of action. Aniracetam has the potential to help with anxiety, stress, and depression due to the effects on the dopamine and serotonin receptors. Whereas, oxiracetam has the potential to help with focus and has more of a stimulatory effect. I say potential, as effects will differ depending on how they interact with each individual.

Aniracetam Benefits

  • Reductions in anxiety and depression
  • Improved learning
  • Increased memory
  • Increased sensory perception
  • Increased cognitive processing
  • Faster reflexes


Oxiracetam Benefits

  • Memory enhancement
  • Learning enhancement
  • Sensory perception enhancement
  • Quicker thinking and processing
  • Improved focus

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A nice little info graph linked to studies on aniracetam, oxiracetam, and other nootropics can be found HERE.

Aniracetam and Oxiracetam Side Effects

Side effects are rare with both of these nootropics, and can often be alleviated with a balanced diet and choline supplementation. Side effects, along with positive effects are subjective, depending on the individual’s biochemical makeup.

Potential Side Effects of Both Aniracetam and Oxiracetam

  • Headaches
  • Nausea
  • Dizziness
  • Insomnia
  • Irritability
  • Gastrointestinal Distress

Aniracetam vs Oxiracetam Review: Conclusion

I have experience with both nootropics and recommend either of them alone, or as a stack, for someone who is looking to enhance their overall performance.

Aniracetam has helped reduce my anxiety and stress levels, increased my verbal fluency, memory, thought processes and sensory perception. I recommend aniracetam as a nootropic for someone who wants to improve their mood and overall cognition.

Oxiracetam is different to aniracetam, as it has had no effect on my anxiety and stress levels. It does, however, make me more zoned in and focused when performing any number of activities, and stacks well with aniracetam.

Which One Should I Try?

If you are looking for a nootropic that has the potential to improve your mood and increase your cognition, try aniracetam. Aniracetam can be purchased HERE.

If mood, anxiety, stress and depression aren’t a concern, and you want a more focus based nootropic, try oxiracetam. Oxiracetam can be purchased HERE.

Both of these nootropics work well when stacked together, to read more on how they stack click HERE.

Always have a choline precursor on hand, approximately 90% of us are choline deficient. Taking choline as a precursor can alleviate any potential side effects and increase the effectiveness of both aniracetam and oxiracetam. A great article on what choline supplement to take and why can be found HERE.

Comment below if you have any questions

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